Xanthine oxidase inhibition for chronic heart failure: is allopurinol the next therapeutic advance in heart failure?
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چکیده
منابع مشابه
Xanthine oxidase inhibition for chronic heart failure: is allopurinol the next therapeutic advance in heart failure?
A substantial body of evidence has accumulated to suggest a role for the xanthine oxidase metabolic pathway in the pathophysiology of chronic heart failure and other cardiovascular diseases.
متن کاملUric acid and xanthine oxidase: perspectives in chronic heart failure
Heart failure continues to be one of the major causes of morbidity and mortality in the western world. Advances in cardiovascular medicine have lead to unearth the possible markers of disease progression. Hyperuricemia is one of the potential metabolic markers for heart failure. In this review, we discuss the beneficial and deleterious role of uric acid and xanthine oxidase in the pathophysiolo...
متن کاملEffects of Xanthine Oxidase Inhibition in Hyperuricemic Heart Failure Patients: The Xanthine Oxidase Inhibition for Hyperuricemic Heart Failure Patients (EXACT-HF) Study.
BACKGROUND Oxidative stress may contribute to heart failure (HF) progression. Inhibiting xanthine oxidase in hyperuricemic HF patients may improve outcomes. METHODS AND RESULTS We randomly assigned 253 patients with symptomatic HF, left ventricular ejection fraction ≤40%, and serum uric acid levels ≥9.5 mg/dL to receive allopurinol (target dose, 600 mg daily) or placebo in a double-blind, mul...
متن کاملXanthine oxidase inhibition and heart failure: novel therapeutic strategy for ventricular dysfunction?
Myocardial dysfunction and heart failure perturb cardiovascular homeostatic signaling pathways as well as initiate a program of molecular, biochemical, and structural modifications to remodel the failing ventricle. Accumulating evidence suggests that the cardiovascular redox state plays an integral role in these processes. In fact, in the failing heart, elevated levels of reactive oxygen specie...
متن کاملInvited commentary Uric acid in chronic heart failure: marker or therapeutic target? Commentary on Uric acid and xanthine oxidase: perspectives in chronic heart failure
Heart failure is one of the leading medical problems in modern medicine regardless of whether we view it from the clinical, prognostic, epidemiological or socio-economic perspective. While current treatment strategies are targeting exclusively the neurohormonal activation, our pathophysiologic understanding has advanced significantly towards an increasingly complex picture including metabolic, ...
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ژورنال
عنوان ژورنال: Heart
سال: 2005
ISSN: 1355-6037
DOI: 10.1136/hrt.2004.057190